Using fluorescence dilution to study Salmonella infection. (360G-Wellcome-092686_Z_10_Z)
We have developed methods based on fluorescence dilution for measuring the dynamics of intracellular Salmonella replication at the population and single cell level. We wish to exploit this to: (a) Analyse the contributions of bacterial virulence proteins to replication in macrophages and epithelial cells. (b) Analyse the influence of host receptors and resistance proteins to intracellular replication and killing of Salmonella. (c) Identify signals leading to bacterial entry into a dormant-like s tate and to determine if these bacteria can be resuscitated. (d) Study the dynamics of bacterial replication at the population and single cell level during growth in infected animals.
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Grant Details
| Amount Awarded | 407687 |
| Applicant Surname | Holden |
| Approval Committee | Immunology and Infectious Disease Funding Committee |
| Award Date | 2010-07-08T00:00:00+00:00 |
| Financial Year | 2009/10 |
| Grant Programme: Title | Project Grant |
| Internal ID | 092686/Z/10/Z |
| Lead Applicant | Prof David Holden |
| Partnership Value | 407687 |
| Planned Dates: End Date | 2013-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2010-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |