Interplay between cAMP and Ca2+ signalling cascades: focus on store-operated Ca2+ entry. (360G-Wellcome-092792_Z_10_A)
The relationship between cyclic adenosine monophosphate (cAMP) and Ca2+ signalling cascades will be investigated in primary pancreatic acinar cells and in established pancreatic cancer cell lines. Particular attention will be given to relationships between cAMP signalling and store-operated Ca2+ entry (SOCE). 1) To determine the effect of Ca2+ signaling on cAMP level, and on Protein Kinase A (PKA) and Exchange protein activated by cAMP (EPAC) activity. 2) To characterise the effect of cAMP increases on Ca2+ signalling mechanisms and specifically on SOCE. 3) To determine the effect of cAMP on junctions between the endoplasmic reticulum (ER) and the plasma membrane (PM) and on proteins involved in SOCE. 4) To determine the relative positioning of Ca2+ sensitive adenylate cyclases and ER-PM junctions.
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Grant Details
Amount Awarded | 1690 |
Applicant Surname | Parker |
Approval Committee | PhD Studentships |
Award Date | 2012-01-27T00:00:00+00:00 |
Financial Year | 2011/12 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 092792/Z/10/A |
Lead Applicant | Mr Tony Parker |
Partnership Value | 1690 |
Planned Dates: End Date | 2014-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2012-02-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | North West |
Sponsor(s) | Prof Alexei Tepikin |