Interplay between cAMP and Ca2+ signalling cascades: focus on store-operated Ca2+ entry. (360G-Wellcome-092792_Z_10_A)

£1,690

The relationship between cyclic adenosine monophosphate (cAMP) and Ca2+ signalling cascades will be investigated in primary pancreatic acinar cells and in established pancreatic cancer cell lines. Particular attention will be given to relationships between cAMP signalling and store-operated Ca2+ entry (SOCE). 1) To determine the effect of Ca2+ signaling on cAMP level, and on Protein Kinase A (PKA) and Exchange protein activated by cAMP (EPAC) activity. 2) To characterise the effect of cAMP increases on Ca2+ signalling mechanisms and specifically on SOCE. 3) To determine the effect of cAMP on junctions between the endoplasmic reticulum (ER) and the plasma membrane (PM) and on proteins involved in SOCE. 4) To determine the relative positioning of Ca2+ sensitive adenylate cyclases and ER-PM junctions.

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Grant Details

Amount Awarded 1690
Applicant Surname Parker
Approval Committee PhD Studentships
Award Date 2012-01-27T00:00:00+00:00
Financial Year 2011/12
Grant Programme: Title PhD Studentship (Basic)
Internal ID 092792/Z/10/A
Lead Applicant Mr Tony Parker
Partnership Value 1690
Planned Dates: End Date 2014-09-30T00:00:00+00:00
Planned Dates: Start Date 2012-02-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West
Sponsor(s) Prof Alexei Tepikin