Phylogeography, Transmission Dynamics and Pathogenesis of Bluetongue. (360G-Wellcome-092806_Z_10_Z)

£979,234

Bluetongue is one of the most important diseases of livestock. The disease is caused by an arbovirus, bluetongue virus (BTV), transmitted by the biting midges. BTV is probably one of the best understood viruses with respect to its structure and replication. However, we have an incomplete understanding of the genetic variability of these viruses. This hampers efforts to determine the origin of some BTV outbreaks making it very difficult to quantify and minimise the risk of future ones. The common thread of this programme is that bluetongue and bluetongue virus are in reality a group of diseases induced by a variety of distinct viruses. BTV can induce a completely asymptomatic infection or kill the infected host. This variability is due to factors related to the virus, the host and the environment. We don t know what differentiate a highly virulent from a less virulent BTV strain. We have a limited understanding of the basis of the wide range of susceptibility to bluetongue displayed by different species and breeds of ruminants. In this ambitious programme, we will provide a multifaceted and holistic approach to understanding key aspects of BTV biology, transmission dynamics and pathogenesis.

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Grant Details

Amount Awarded 979234
Applicant Surname Palmarini
Approval Committee Immunology and Infectious Disease Funding Committee
Award Date 2010-07-08T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title Programme Grant
Internal ID 092806/Z/10/Z
Lead Applicant Prof Massimo Palmarini
Other Applicant(s) Dr Roman Biek, Prof Peter Mertens
Partnership Value 979234
Planned Dates: End Date 2017-02-28T00:00:00+00:00
Planned Dates: Start Date 2011-07-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland