Transgenic animals: Genetically modified mice in Britain and the United States, 1970-2000 (360G-Wellcome-092990_Z_10_Z)

£85,708

To explore the history of GM mice, I will begin by studying technical innovations in mammalian embryology and reproductive physiology in the 1970s. In particular, I will consider how the techniques travelled, through multiple exchanges between laboratories in Britain and the US, and how this research was variously combined with recombinant DNA technologies developed in the 1970s to produce multiple transgenic mice in 1980-1. Then I will explore the parallel lines of research on embryonic carcinoma (EC) and embryonic stem (ES) cells in the 1970s and 1980s. To assess the effect of the new kinds of animals on the infrastructure of their breeding and supply, and the stabilisation of their production, I will use as a case study the MRC Radiobiology Unit (Mammalian Genetics Unit since 1995) in Harwell, a stock centre and research facility for mouse experimentation, in the 1980-1990s. I will pay special attention to criteria for genetic modification and negotiations over the status of the mice. Finally, to analyse the (contested) use of GM mice as models of human disease, I will consider the induction of breast cancer through oncogene insertion.

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Grant Details

Amount Awarded 85708
Applicant Surname Myelnikov
Approval Committee Medical History and Humanities Funding Committee
Award Date 2010-06-10T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title PhD Studentship in H&SS
Internal ID 092990/Z/10/Z
Lead Applicant Mr Dmitriy Myelnikov
Partnership Value 85708
Planned Dates: End Date 2013-09-30T00:00:00+00:00
Planned Dates: Start Date 2010-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England
Sponsor(s) Prof Nick Hopwood