High Resolution Imaging in 3D. (360G-Wellcome-093026_Z_10_Z)
The importance of microscopy in biomedical research cannot be overestimated, because it enables us to visualise the inner workings of the cell. We now know that in order for the cell to function properly, it needs to generate and maintain a number of different membrane compartments. This is achieved by packaging proteins and other molecules into vesicles that traffic from one compartment to another. The Robinson lab is investigating how different membrane proteins are packaged into the right kin ds of vesicles; the Buss lab works on the molecular motors that move the vesicles and organelles around in the cell; the Luzio lab investigates the docking and fusion of vesicles and organelles, in particular lysosomes; and the Griffiths lab focuses on how cytotoxic T lymphocytes (CTLs) orchestrate all their different types of trafficking machinery to kill target cells. Questions we will be addressing using the new microscopes include how different types of vesicles form in space and time, how t he motor protein myosin VI recruits its different partners in living cells, how organelles become tethered to each other prior to fusion, and how the immunological synapses of CTLs are formed.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
Amount Awarded | 747000 |
Applicant Surname | Robinson |
Approval Committee | Molecules, Genes and Cells Funding Committee |
Award Date | 2010-10-14T00:00:00+00:00 |
Financial Year | 2010/11 |
Grant Programme: Title | Equipment & Resources: Inactive Scheme |
Internal ID | 093026/Z/10/Z |
Lead Applicant | Prof Margaret Robinson |
Other Applicant(s) | Prof Folma Buss, Prof Gillian Griffiths, Prof J. Paul Luzio |
Partnership Value | 747000 |
Planned Dates: End Date | 2016-06-27T00:00:00+00:00 |
Planned Dates: Start Date | 2011-06-28T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |