High Resolution Imaging in 3D. (360G-Wellcome-093026_Z_10_Z)

£747,000

The importance of microscopy in biomedical research cannot be overestimated, because it enables us to visualise the inner workings of the cell. We now know that in order for the cell to function properly, it needs to generate and maintain a number of different membrane compartments. This is achieved by packaging proteins and other molecules into vesicles that traffic from one compartment to another. The Robinson lab is investigating how different membrane proteins are packaged into the right kin ds of vesicles; the Buss lab works on the molecular motors that move the vesicles and organelles around in the cell; the Luzio lab investigates the docking and fusion of vesicles and organelles, in particular lysosomes; and the Griffiths lab focuses on how cytotoxic T lymphocytes (CTLs) orchestrate all their different types of trafficking machinery to kill target cells. Questions we will be addressing using the new microscopes include how different types of vesicles form in space and time, how t he motor protein myosin VI recruits its different partners in living cells, how organelles become tethered to each other prior to fusion, and how the immunological synapses of CTLs are formed.

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Grant Details

Amount Awarded 747000
Applicant Surname Robinson
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2010-10-14T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title Equipment & Resources: Inactive Scheme
Internal ID 093026/Z/10/Z
Lead Applicant Prof Margaret Robinson
Other Applicant(s) Prof Folma Buss, Prof Gillian Griffiths, Prof J. Paul Luzio
Partnership Value 747000
Planned Dates: End Date 2016-06-27T00:00:00+00:00
Planned Dates: Start Date 2011-06-28T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England