Development of monoclonal antibody products for post-exposure prophylaxis of rabies. (360G-Wellcome-093092_Z_10_Z)
This research project will involve the identification and characterization of monoclonal antibodies (mAbs) that neutralize classic rabies virus strains and emerging lyssaviruses. Antibodies targeting different virus strains and different epitopes of the rabies glycoprotein will be combined into cocktails that will be tested to determine their ability to prevent virus escapes under selection pressure. The best candidates will be cloned and used to develop two products a cocktail of full-size mA bs suitable for the replacement of RIG in standard post-exposure prophylaxis, and a range of candidate antibody fragments with the ability to traverse the blood-brain barrier, targeting elimination of rabies virus in the CNS and prevention of rabies encephalitis. mAb cocktail products will be expressed in plants to overcome economic barriers preventing the development of such prophylactics containing multiple mAbs and to ensure that the products can be produced on a large enough scale to cope wi th demand. The plant-derived antibodies and fragments will be characterized in vitro in terms of their structure and binding properties, and will be tested in vitro and in vivo for their ability to neutralize rabies virus infections in an animal model.
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Grant Details
Amount Awarded | 292519 |
Applicant Surname | Ma |
Approval Committee | Immunology and Infectious Disease Funding Committee |
Award Date | 2010-10-05T00:00:00+00:00 |
Financial Year | 2010/11 |
Grant Programme: Title | Project Grant |
Internal ID | 093092/Z/10/Z |
Lead Applicant | Prof Julian Ma |
Partnership Value | 292519 |
Planned Dates: End Date | 2015-04-30T00:00:00+00:00 |
Planned Dates: Start Date | 2011-05-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |