Imaging mechanisms of energy failure following head injury. (360G-Wellcome-093267_Z_10_Z)
Traumatic brain injury (TBI) caused over 170,000 NHS hospital admissions in 2008, requiring over 0.5 million acute hospital bed-days, and over 50,000 intensive care unit bed-days annually. TBI is amongst the most important causes of death in young adults. Survivors experience an enormous burden of physical disability, neurocognitive deficits, and neuropsychiatric sequelae. Despite this, outcome following injury has improved through the provision of protocol driven therapy aimed at preventing an d treating secondary ischaemic insults. However, energy failure may be due to mechanisms other than classical ischaemia, and this may explain the failure of pharmacological neuroprotective therapies. The research detailed in this application aims to improve our understanding of the mechanisms of energy failure following TBI using magnetic resonance imaging, proton spectroscopy and positron emission tomography to map the extent and spatial distribution of metabolic derangements. These will differ entiate classical ischaemia, regional hypoxia secondary to microvascular injury and mitochondrial dysfunction. Sequential measurements of n-acetylaspartate, a mitochondrial metabolite, will address whether metabolic derangements are reversible and represent mitochondrial dysfunction, or irreversible and represent on going neuronal loss. Such data may provide important advances in the development and implementation of successful neuroprotective therapies.
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Grant Details
Amount Awarded | 184299 |
Applicant Surname | Coles |
Approval Committee | Cognitive and Higher Systems Funding Committee |
Award Date | 2010-10-07T00:00:00+00:00 |
Financial Year | 2010/11 |
Grant Programme: Title | Project Grant |
Internal ID | 093267/Z/10/Z |
Lead Applicant | Dr Jonathan Coles |
Other Applicant(s) | Dr Tim Fryer, Prof David Menon |
Partnership Value | 184299 |
Planned Dates: End Date | 2013-02-28T00:00:00+00:00 |
Planned Dates: Start Date | 2011-03-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |