Reward prediction in health and disease. (360G-Wellcome-093270_Z_10_Z)
Our goal is to characterise and extend our understanding of behavioural and brain signatures of prediction-dependent responding in schizophrenia. The behavioural symptoms of schizophrenia, as well as the implications of dopaminergic alterations, suggest that abnormal prediction error signals and predictions may be key to understanding the condition. Several functional neuroimaging studies have provided evidence in favour of this view. However, the functions of prediction errors in learning and b ehaviour are complex and cannot be adequately characterised solely in terms of their presence and magnitude. We hypothesise that a detailed understanding of the adaptivity of prediction error coding and the variability of reward prediction in relation to background environmental characteristics will bring us closer to understanding the positive symptoms of schizophrenia. Our aims are therefore to explore these two features of error-dependent learning using complementary studies in control partic ipants and in patients with schizophrenia. Our specific goal is to identify changes in prediction error sensitivity to adaptation and contingency in patients and to characterise the extent to which these signals in healthy controls are susceptible to perturbations induced by dopaminergic drugs (L-Dopa and sulpiride). In doing so, we will provide critical insights to the neurobiology of positive symptoms of schizophrenia.
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Grant Details
Amount Awarded | 381826 |
Applicant Surname | Fletcher |
Approval Committee | Cognitive and Higher Systems Funding Committee |
Award Date | 2011-02-21T00:00:00+00:00 |
Financial Year | 2010/11 |
Grant Programme: Title | Project Grant |
Internal ID | 093270/Z/10/Z |
Lead Applicant | Prof Paul Fletcher |
Other Applicant(s) | Prof Wolfram Schultz |
Partnership Value | 381826 |
Planned Dates: End Date | 2015-10-31T00:00:00+00:00 |
Planned Dates: Start Date | 2011-11-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |