Dissecting compulsivity. (360G-Wellcome-093705_Z_10_Z)
Compulsivity, or the repetition of behaviours despite negative consequences, defines a range of psychiatric disorders from addiction to obsessive-compulsive disorder. Disorders of binge drinking and binge eating in obesity are prominent public health issues. Influential models of addiction, namely that of compulsivity and incentive motivation, define the field of addiction; yet, remarkably, there is a paucity of clinical research to support these models. We tend also to conceptualize habit an d motivation as related to reward and incentive; however, the relationship of the conditioned avoidance response to habit and motivation is not known. The role of dopamine to negative stimuli and this motivational escape response is also poorly understood. The proposal aims to address these questions. To achieve this, I shall adopt a highly innovative approach combining carefully designed novel cognitive paradigms and fMRI in clinical and high risk populations. I will also use combined c omputational modeling and single unit electrophysiology in awake human subjects to assess dopaminergic function to negative stimuli. Empirical data will be used to develop a mechanistic model of the construct of compulsivity and its relationship to factors that may influence its expression such as biological susceptibility, motivation, aversive stimuli and dopamine.
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Grant Details
Amount Awarded | 698954 |
Applicant Surname | Voon |
Approval Committee | Clinical Interview Committee |
Award Date | 2010-11-25T00:00:00+00:00 |
Financial Year | 2010/11 |
Grant Programme: Title | Intermediate Clinical Fellowship |
Internal ID | 093705/Z/10/Z |
Lead Applicant | Dr Valerie Voon |
Partnership Value | 698954 |
Planned Dates: End Date | 2015-09-01T00:00:00+00:00 |
Planned Dates: Start Date | 2011-09-02T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof Edward Bullmore |