Role of ascending cholinergic and monoaminergic systems in absence epilepsy (360G-Wellcome-093763_Z_10_Z)

£143,094

The expression of absence seizures in humans and experimental models strongly depends on the behavioural state. However, the precise contribution of different neurotransmitters that control vigilance states to the generation of these non-convulsive seizures is still controversial, mainly because of the inability to selectively manipulate these neurotransmitter systems using conventional tools. Using an optogenetics approach that will allows us to excite or inhibit neuronal populations with high temporal resolution and strong cellular selectivity, the aim of this project is to investigate the effect(s) of the cholinergic (Ach), noradrenergic (NA) and serotoninergic (5HT) systems in the generation and maintenance of absence seizures in well established mouse models of this neurological disease. The results of this study will further our understanding of the role(s) of these neurotransmitters in absence seizures, and may lead to the identification of novel therapeutic targets for the treatment of absence epilepsy.

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Grant Details

Amount Awarded 143094
Applicant Surname Venzi
Approval Committee Neurosciences And Mental Health
Award Date 2010-06-14T00:00:00+00:00
Financial Year 2009/10
Grant Programme: Title PhD Studentship (Basic)
Internal ID 093763/Z/10/Z
Lead Applicant Mr Marcello Venzi
Partnership Value 143094
Planned Dates: End Date 2014-10-31T00:00:00+00:00
Planned Dates: Start Date 2010-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Wales
Sponsor(s) Prof Vincenzo Crunelli