Structural analysis of Wntch signalling in Drosophila. (360G-Wellcome-094222_Z_10_Z)

£344,942

Analysis of signalling during development has revealed a consistent and pervasive relationship between Notch and Wnt signalling suggesting that they form a single functional module. Notch encodes a member of a family of cell surface receptors that acts as membrane tethered transcription factors while Wnt represents a family of ligands that interact with receptors to modulate cytoskeletal activity and transcription. Work in Drosophila has revealed that Notch has the ability to modulate Wnt signal ling independently of its transcriptional activity and that this effect has an important function in processes of cell fate assignation. Our studies with Drosophila have uncovered an activity of Notch which targets the activated form of -catenin, the effector of the transcriptional activity of Wnt, and modulates its amount and activity. This function relies on the ligand independent traffic of the Notch receptor, provides a buffer for Wnt signalling and suggests a framework to think about Notch as a multifunctional receptor. Here I propose to probe the mechanisms that govern the interactions between Wnt and Notch signalling using Drosophila as a model system.

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Grant Details

Amount Awarded 344942
Applicant Surname Martinez-Arias
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2011-03-09T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title Project Grant
Internal ID 094222/Z/10/Z
Lead Applicant Prof Alfonso Martinez-Arias
Partnership Value 344942
Planned Dates: End Date 2014-12-31T00:00:00+00:00
Planned Dates: Start Date 2012-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England