Structural analysis of Wntch signalling in Drosophila. (360G-Wellcome-094222_Z_10_Z)
Analysis of signalling during development has revealed a consistent and pervasive relationship between Notch and Wnt signalling suggesting that they form a single functional module. Notch encodes a member of a family of cell surface receptors that acts as membrane tethered transcription factors while Wnt represents a family of ligands that interact with receptors to modulate cytoskeletal activity and transcription. Work in Drosophila has revealed that Notch has the ability to modulate Wnt signal ling independently of its transcriptional activity and that this effect has an important function in processes of cell fate assignation. Our studies with Drosophila have uncovered an activity of Notch which targets the activated form of -catenin, the effector of the transcriptional activity of Wnt, and modulates its amount and activity. This function relies on the ligand independent traffic of the Notch receptor, provides a buffer for Wnt signalling and suggests a framework to think about Notch as a multifunctional receptor. Here I propose to probe the mechanisms that govern the interactions between Wnt and Notch signalling using Drosophila as a model system.
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Grant Details
Amount Awarded | 344942 |
Applicant Surname | Martinez-Arias |
Approval Committee | Molecules, Genes and Cells Funding Committee |
Award Date | 2011-03-09T00:00:00+00:00 |
Financial Year | 2010/11 |
Grant Programme: Title | Project Grant |
Internal ID | 094222/Z/10/Z |
Lead Applicant | Prof Alfonso Martinez-Arias |
Partnership Value | 344942 |
Planned Dates: End Date | 2014-12-31T00:00:00+00:00 |
Planned Dates: Start Date | 2012-01-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |