Resident and Inflammatory Macrophages in the Intestine. (360G-Wellcome-094763_Z_10_Z)

£390,724

Macrophages (mφ) are abundant in the normal intestine and it is essential that their activation is regulated properly. Although they are partially activated and are crucial for maintaining homeostasis to commensal bacteria, they do this without causing inflammation. During inflammatory bowel disease, control of mφ activation is lost and they cause pathology, meaning they are attractive targets for therapy. However the mechanisms of this regulation are unclear and it is not known how th e mφ populations found in healthy and inflamed intestine are related to each other. Here we will exploit newly refined techniques for characterising colonic mφ in mice and powerful in vivo models to study two novel aspects of intestinal mφ biology. We will examine the relationships between two phenotypic subsets we have defined based on the expression of Ly6C and the CX3CR1 fractalkine receptor in intestinal inflammation caused by DSS, Helicobacter hepaticus and Toxoplasma gondii. The role of the inhibitory CD200R1 in regulating mφ function will be explored. By characterising these cells at the molecular level, our studies will help understand how the normal intestinal immune system adapts to commensals and will define the processes which determine how the mucosal mφ population changes during inflammation and infection.

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Grant Details

Amount Awarded 390724
Applicant Surname Mowat
Approval Committee Immunology and Infectious Disease Funding Committee
Award Date 2011-03-07T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title Project Grant
Internal ID 094763/Z/10/Z
Lead Applicant Prof Allan Mowat
Other Applicant(s) Dr Marika Kullberg
Partnership Value 390724
Planned Dates: End Date 2015-10-31T00:00:00+00:00
Planned Dates: Start Date 2011-11-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland