Resident and Inflammatory Macrophages in the Intestine. (360G-Wellcome-094763_Z_10_Z)
Macrophages (mφ) are abundant in the normal intestine and it is essential that their activation is regulated properly. Although they are partially activated and are crucial for maintaining homeostasis to commensal bacteria, they do this without causing inflammation. During inflammatory bowel disease, control of mφ activation is lost and they cause pathology, meaning they are attractive targets for therapy. However the mechanisms of this regulation are unclear and it is not known how th e mφ populations found in healthy and inflamed intestine are related to each other. Here we will exploit newly refined techniques for characterising colonic mφ in mice and powerful in vivo models to study two novel aspects of intestinal mφ biology. We will examine the relationships between two phenotypic subsets we have defined based on the expression of Ly6C and the CX3CR1 fractalkine receptor in intestinal inflammation caused by DSS, Helicobacter hepaticus and Toxoplasma gondii. The role of the inhibitory CD200R1 in regulating mφ function will be explored. By characterising these cells at the molecular level, our studies will help understand how the normal intestinal immune system adapts to commensals and will define the processes which determine how the mucosal mφ population changes during inflammation and infection.
Where is this data from?
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Grant Details
Amount Awarded | 390724 |
Applicant Surname | Mowat |
Approval Committee | Immunology and Infectious Disease Funding Committee |
Award Date | 2011-03-07T00:00:00+00:00 |
Financial Year | 2010/11 |
Grant Programme: Title | Project Grant |
Internal ID | 094763/Z/10/Z |
Lead Applicant | Prof Allan Mowat |
Other Applicant(s) | Dr Marika Kullberg |
Partnership Value | 390724 |
Planned Dates: End Date | 2015-10-31T00:00:00+00:00 |
Planned Dates: Start Date | 2011-11-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Scotland |