Sheffield Human 3T MR Imaging & Spectroscopy Facility. (360G-Wellcome-094834_Z_10_Z)

Part capital-funding for a whole-body, human, in-vivo, superconducting Magnetic Resonance (MR) research system is required to provide a continued, sustainable, leading-edge, multi-nuclear, 3T MR imaging resource based in Sheffield. This equipment will facilitate ongoing and novel investigations. Current key areas of application include: a) clinical neuroimaging - cerebrovascular dysfunction in diabetes - CNS pain matrix associated with chronic neuropathies - schizophrenia fMRI correlates of auditory hallucinations, cognitive status and therapeutic intervention - neuro-oncology lesion characterization - neurodegenerative diseases such as the ataxias and amyotrophic lateral sclerosis (emphasis on therapy monitoring) - metal ion exposure sequalae of hip-implant resurfacing - computational neuro-modeling for clinical decision support b) basic science fMRI neuro- - emotion and executive function, notably in dramatic arts - musical rhythm performance - mathematical process ing - mistruths c) Inhaled hyperpolarized 3-He and 129-Xe lung imaging with simultaneous multi-nuclear excitation d) Hyperpolarized 129-Xe labeling and 1-H imaging for linked cardiac and brain perfusion assessment We also aim to conjoin imaging measures of CNS, heart and lung status and function. Provision of state-of-the-art imaging equipment will help to drive and facilitate other areas of research, in particular, in-vivo monitoring following translational research / novel interventi ons, including those developed in the part-Wellcome-funded Medical School.