Population genetics of resistance to alternative insecticides in southern Ghana (360G-Wellcome-094960_Z_10_Z)

Resistance to DDT and pyrethroids is now ubiquitous in Anopheles gambiae in southern Ghana (Coetzee et al 2006; Adasi & Hemingway 2008; Adeniran et al. 2009; Mawejje et al. in prep), reducing insecticidal efficacy for malaria control. The national malaria control programme (NMCP) urgently needs to switch to application of insecticides with a different mode of action, i.e. carbamates or organophosphates, as alternatives or supplements to pyrethroids. However resistance to carbamates, the more favoured alternative, has been documented in Ghana, necessitating extremely careful application of insecticide to manage the development and spread of resistance. To achieve this objective, data are required on how best to predict the dynamics of carbamate resistance. This is the primary goal addressed by the current project. The goal will be achieved via determination of how geographical variation in resistance to carbamates (and to a more limited extent organophosphates) relates to, and can be predicted, by gene flow, assesed using neutral microsatellite markers, and a strongly resistance-linked mutation ace-1R. Since the predictive value of ace-1R frequencies could be compromised if alleles have independent origins, the project will also conduct long range haplotype analysis both to determine mutational origins and to quantify the strength of selection acting on ace-1R.

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Grant Details

Amount Awarded 92867
Applicant Surname Essandoh
Approval Committee International Interview Committee
Award Date 2010-11-23T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title International Masters Fellowship
Internal ID 094960/Z/10/Z
Lead Applicant Mr John Essandoh
Partnership Value 92867
Planned Dates: End Date 2013-09-30T00:00:00+00:00
Planned Dates: Start Date 2011-03-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West
Sponsor(s) Dr Alexander Egyir-Yawson, Dr David Weetman