Complementary studies of learning and motivation in psychosis and pathological hyperphagia. (360G-Wellcome-095692_Z_11_Z)
The proposal is based on the hypothesis that psychosis and pathological hyperphagia may be understood in terms of differing perturbations within reinforcement learning circuitry and that parallel explorations of these perturbations will generate complementary insights both to the conditions themselves and to the neurobiology of reward processing generally. The following are the key goals: To conduct parallel clinical and normative studies leading to a detailed understanding of how primary ( food) and secondary (financial) rewards, as well as environmental predictors of those rewards, are associated with deranged (psychosis) or enhanced (MC4R deficiency) motivation and responding. To further our neural understanding of these two serious health problems and, in doing so, enhance knowledge of how and why humans respond to reinforcing stimuli. To gain insights into how reinforcement learning circuitry is integrated with endocrine and metabolic signals, elucidating the ways in whi ch these signals translate into complex behaviours including attention, motivation and learning. To examine general motivational disturbances in psychosis under different circumstances (early onset psychosis, established psychosis, ketamine-induced psychosis) and to extend this to examine food-related motivational changes pertinent to the eating and metabolic changes found in association with schizophrenia and antipsychotic treatment.
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Grant Details
Amount Awarded | 998974 |
Applicant Surname | Fletcher |
Approval Committee | Clinical Interview Committee |
Award Date | 2011-05-26T00:00:00+00:00 |
Financial Year | 2010/11 |
Grant Programme: Title | Senior Research Fellowship Clinical Renewal |
Internal ID | 095692/Z/11/Z |
Lead Applicant | Prof Paul Fletcher |
Partnership Value | 998974 |
Planned Dates: End Date | 2018-01-01T00:00:00+00:00 |
Planned Dates: Start Date | 2012-01-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof Edward Bullmore |