Deprotection of cohesion in meiosis II (360G-Wellcome-096994_Z_11_Z)

£147,915

The faithful segregation of chromosomes requires the cohesion of sister chromatids, a function mediated by the cohesin complex. In mitosis, cohesin iscleaved in one step along the length of the chromosomes to allow sister chromatid segregation. In meiosis, however, cohesin is cleaved in a step-wise manner. Cohesin at chromosome arms is cleaved in meiosis I to allow homologue segregation but protected around the centromeres until meiosis II, when its cleavage triggers sister chromatid segregation. How centromeric cohesin is "deprotected" to allow its cleavage during meiosis II is unknown. The overall aim of my project is to determine how pericentromeric cohesin becomes susceptible to cleavage in meiosis II. To do this, I will first identify post-translational modifications of cohesin in meiosis II and their role in allowing cohesin cleavage. Secondly, I will investigate how the cohesin protector Sgo1/PP2ARts1 is inactivated in meiosis II. I will determinethe behaviour of the protector throughout meiosis and investigate why it is lost from the pericentromere at the end of meiosis II. Furthermore, I will interactors and post-translattional modifications of Sgo1 and study how these affect its function. Overall, I will gain insight into the mechanisms governing the cohesin deprotection in meiosis II.

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Grant Details

Amount Awarded 147915
Applicant Surname Galander
Approval Committee Molecules, Genes and Cells Funding Committee
Award Date 2011-07-12T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title PhD Studentship (Basic)
Internal ID 096994/Z/11/Z
Lead Applicant Mr Stefan Galander
Partnership Value 147915
Planned Dates: End Date 2015-09-30T00:00:00+00:00
Planned Dates: Start Date 2011-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland
Sponsor(s) Prof Jean Beggs