The role of cervical innate immunity in preterm birth. (360G-Wellcome-097228_Z_11_Z)
The ultimate aim of this research is to reduce the number women delivering prematurely. The study has two aspects that are of particular clinical relevance: (1) it seems likely that early identification of women who are at risk of bacteria triggered PTB will be essential to intervening in a timely fashion ? phenotyping maternal antimicrobial defences at an early gestation offers a logical way to do this; (2) the idea of therapeutically augmenting cervical antimicrobial activity using vector mediated gene delivery to cervical epithelium is a highly novel approach that has the potential to prevent ascending bacterial colonization of the placenta and membranes. As such, the project is poised at the interface of clinical and basic science and may make a significant contribution to reducing the risk of preterm birth and subsequently both neonatal morbidity and mortality, and the serious long term disability associated with prematurity.
Where is this data from?
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Grant Details
| Amount Awarded | 215215 |
| Applicant Surname | James |
| Approval Committee | Clinical Interview Committee |
| Award Date | 2011-06-20T00:00:00+00:00 |
| Financial Year | 2010/11 |
| Grant Programme: Title | Research Training Fellowship |
| Internal ID | 097228/Z/11/Z |
| Lead Applicant | Dr Catherine James |
| Partnership Name | Research Training Fellowship/Wellbeing of Women |
| Partnership Value | 215215 |
| Planned Dates: End Date | 2015-10-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2011-10-31T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |
| Sponsor(s) | Prof Nigel Klein |