Combating Infectious Disease: Computational Approaches in Translational Science (CIDCATS) - 'Application of plasma technology for the elimination of intracellular infections in vitro' (360G-Wellcome-097323_Z_11_Z)

£146,502

Currently, limited approaches are available to treat infections due to inherent and acquired resistance to existing drugs. Ionised gas or "plasma", the fourth state of matter, is of interest for biomedicine for the production of reactive species, electrons, ions and UV light. Plasmas have been demonstrated to have antimicrobial properties. They can eliminate free-living microorganisms in a time- and dose-dependent fashion; however, it is unknown whether they could clear intracellular infections without damaging the eukaryotic host cell. In this project, the student will address the hypothesis that an atmospheric pressure dielectric barrier discharge (AP-DBD) plasma jet can eliminate intracellular pathogens in macrophages without affecting the integrity and viability of the host cell. This will be a proof-of-principle study using intracellular growth within a macrophage of the bacterial pathogen Salmonella enterica in vitro as a model. We will define parameters for reproducible plasma treatment with AP-DBD plasma jet and will identify the main biological

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Grant Details

Amount Awarded 146502
Applicant Surname Maldonado
Approval Committee Immunology and Infectious Disease Funding Committee
Award Date 2011-08-31T00:00:00+00:00
Financial Year 2010/11
Grant Programme: Title PhD Studentship (Basic)
Internal ID 097323/Z/11/Z
Lead Applicant Ms Angela Maldonado
Partnership Value 146502
Planned Dates: End Date 2015-09-30T00:00:00+00:00
Planned Dates: Start Date 2011-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Yorkshire and the Humber
Sponsor(s) Prof Deborah Smith