Combating Infectious Disease: Computational Approaches in Translational Science (CIDCATS) - 'Application of plasma technology for the elimination of intracellular infections in vitro' (360G-Wellcome-097323_Z_11_Z)
Currently, limited approaches are available to treat infections due to inherent and acquired resistance to existing drugs. Ionised gas or "plasma", the fourth state of matter, is of interest for biomedicine for the production of reactive species, electrons, ions and UV light. Plasmas have been demonstrated to have antimicrobial properties. They can eliminate free-living microorganisms in a time- and dose-dependent fashion; however, it is unknown whether they could clear intracellular infections without damaging the eukaryotic host cell. In this project, the student will address the hypothesis that an atmospheric pressure dielectric barrier discharge (AP-DBD) plasma jet can eliminate intracellular pathogens in macrophages without affecting the integrity and viability of the host cell. This will be a proof-of-principle study using intracellular growth within a macrophage of the bacterial pathogen Salmonella enterica in vitro as a model. We will define parameters for reproducible plasma treatment with AP-DBD plasma jet and will identify the main biological
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Grant Details
Amount Awarded | 146502 |
Applicant Surname | Maldonado |
Approval Committee | Immunology and Infectious Disease Funding Committee |
Award Date | 2011-08-31T00:00:00+00:00 |
Financial Year | 2010/11 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 097323/Z/11/Z |
Lead Applicant | Ms Angela Maldonado |
Partnership Value | 146502 |
Planned Dates: End Date | 2015-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2011-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Yorkshire and the Humber |
Sponsor(s) | Prof Deborah Smith |