Structural biology of protein folding on the ribosome: exploring mechanisms biochemically and computationally. (360G-Wellcome-097806_Z_11_A)
We are delineating the very early dynamic structural events of protein synthesis as they occur on the ribosome. Despite the abundance of ribosome structures, the structural properties of the emerging nascent polypeptide chain (NC) are almost entirely absent. We apply NMR spectroscopy to the 2.5MDa ribosomal particle, as it has the unique ability to describe the structural and dynamical characteristics of fledgling NCs emerging during biosynthesis.
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Grant Details
| Amount Awarded | 130000 |
| Applicant Surname | Christodoulou |
| Approval Committee | Science Enhancement Committee |
| Award Date | 2014-12-08T00:00:00+00:00 |
| Financial Year | 2014/15 |
| Grant Programme: Title | Enhancement |
| Internal ID | 097806/Z/11/A |
| Lead Applicant | Prof John Christodoulou |
| Partnership Value | 130000 |
| Planned Dates: End Date | 2017-10-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2015-03-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |