Combination therapy for obesity and type 2 diabetes treatment (360G-Wellcome-098012_B_11_A)

£199,253

Drugs augmenting serotonin bioavailability are among the most clinically effective compounds for weight loss and represent the gold-standard for obesity treatment research. Due to sibutramine's withdrawal from the clinic and the recent failure of the serotonin2C receptor agonist lorcaserin to achieve FDA approval, a major unmet clinical need has emerged. Here we propose a refined strategy to dissociate and manipulate a critical serotonin energy balance pathway in an effort to circumvent off-tar get effects produced by global serotonergic compounds and selective serotonin receptor agonists. Building on work generated in the previous funding period where we characterised a downstream pathway required for serotonin to regulate energy homeostasis, here we propose cutting-edge techniques coupled with recently developed tools to delineate and manipulate in real-time serotonin efferents providing these critical inputs to coordinate energy balance. Furthermore, we will interrogate the effect of dietary choice and adiposity on serotonin neuron sensitivity to these inputs and nutritional signals. Finally, we will delineate nutrients and nutritional cues that directly influence the sertotonin neuron activity, with the aim of revealing new system-specific targets for obesity pharmacotherapy.

Where is this data from?

This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.

Grant Details

Amount Awarded 199253
Applicant Surname Heisler
Approval Committee Science Enhancement Committee
Award Date 2015-04-08T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title Enhancement
Internal ID 098012/B/11/A
Lead Applicant Prof Lora Heisler
Partnership Value 199253
Planned Dates: End Date 2017-05-31T00:00:00+00:00
Planned Dates: Start Date 2015-06-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Scotland
Sponsor(s) Prof Peter Morgan