Development of a cytotopically-modified antithrombotic agent for prevention of acute intra-graft thrombosis in transplantation (360G-Wellcome-098300_Z_12_Z)

£1,580,495

"Dr Richard Smith and Professor Anthony Darling of the MRC Centre for Transplantation at King's College London have received a Translation Award to develop a peptide-based anti-thrombin agent that is capable of rendering a transplanted organ resistant to thrombosis without using systemic anticoagulation . This is achieved by perfusing the organ with a membraneinteractive ("cytotopic") agent (which sticks to the organ vasculature) and then flushing out excess agent prior to transplantation. At least 25% of patients currently on the waiting list for renal transplantation are there because they have pre-existing antibodies against potential donor tissue. Attempts to transplant organs into such patients result in thrombosis within the organ which is difficult to treat with conventional anticoagulants and can lead to severe graft damage. The translation programme will refine processes for the manufacture of the lead cytotopic agent ("Thrombalexin') and will include safety studies to enable a firstin- man study in patients at high risk of intra-graft thrombosis following renal transplantation."

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Grant Details

Amount Awarded 1580495
Applicant Surname Smith
Approval Committee Technology Transfer Challenge Committee
Award Date 2012-03-01T00:00:00+00:00
Financial Year 2011/12
Grant Programme: Title Translation Award
Internal ID 098300/Z/12/Z
Lead Applicant Dr Richard Smith
Other Applicant(s) Prof Anthony Dorling, Prof Steven Sacks
Partnership Value 1580495
Planned Dates: End Date 2018-05-01T00:00:00+00:00
Planned Dates: Start Date 2013-04-30T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London