New insights from neonatal diabetes (360G-Wellcome-098395_Z_12_A)

£1,456,000

What is the molecular genetic basis of severe beta-cell dysfunction resulting in neonatal diabetes? Defining known and novel causes will allow us to address these research questions: (i) What are the critical transcription factors for normal development of the human beta cell and other pancreatic cell types i (ii) What are the key genes and regulatory mechanisms for the maintenance of normal beta-cell number and normal insulin secretion in man? (iii) What is the function of the genes t hat cause neonatal diabetes in the beta-cell and other tissues?

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Grant Details

Amount Awarded 1456000
Applicant Surname Ellard
Approval Committee Science Interview Panel
Award Date 2012-05-15T00:00:00+00:00
Financial Year 2011/12
Grant Programme: Title Investigator Award in Science
Internal ID 098395/Z/12/A
Lead Applicant Prof Sian Ellard
Partnership Value 1456000
Planned Dates: End Date 2019-09-30T00:00:00+00:00
Planned Dates: Start Date 2012-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South West