Two-photon imaging and optogenetics in the mouse midbrain (360G-Wellcome-098400_A_12_A)

£171,360

The brain processes and responds to information from the outside world using neurons - cells that are wired up in a network like a computer. Neurons receive input on so-called dendrites - long extensions resembling tree branches - which have properties that allow them to transform information before it reaches the output end of the neuron. Understanding how the brain processes information requires knowing how individual neurons and dendrites integrate input. In the primitive brain areas that con trol instinctive behaviours, neurons have a small number of dendrites, which simplifies the goal of fully understanding how each neuron processes information. In this project I aim to find out how the dendrites of primitive neurons integrate input. I will work on a mouse brain circuit involved in aggression, and begin by examining the integration properties of dendrites. I will then investigate how specific brain areas are connected to these dendrites and study how they processes information a rriving from each area. In the last stage I will use genetic methods to study the specific neurons that control aggression. The results of these experiments will provide insight specifically into how aggression neurons integrate input, and more generally into how primitive brain areas process information

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Grant Details

Amount Awarded 171360
Applicant Surname Branco
Approval Committee Science Enhancement Committee
Award Date 2016-06-08T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Enhancement
Internal ID 098400/A/12/A
Lead Applicant Prof Tiago Branco
Partnership Value 171360
Planned Dates: End Date 2017-09-30T00:00:00+00:00
Planned Dates: Start Date 2016-07-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London