Dendritic integration in the ventromedial nucleus of the hypothalamus. (360G-Wellcome-098400_Z_12_Z)
The main goal of this project is to investigate the input-output function of single neurons in the ventromedial nucleus of the hypothalamus (VMH), and test whether dendritic computations can contribute to information processing in these neurons, in particular in the circuit that controls aggressive behaviour. There are three initial key questions: (1) How do dendrites in VMH neurons integrate excitatory synaptic input? (2) What is the distribution of excitatory synapses from different inpu t pathways on VMH dendrites? (3) How do VMH neurons integrate information arriving from specific brain areas? These questions will be addressed in actute brain slices, using whole-cell recordings, 2-photon glutamate uncaging, and optogenetics together with calcium imaging. Specific brain regions will be targeted by stereotaxic injections, and axons and synapses visualized with genetic and immunohistochemistry methods. These experiments will be done in the ventrolateral VMH subdivision (VM Hvl), which control aggressive and sexual behaviour, and will identify the repertoire of dendritic computations of the VMHvl, as well as how they might be engaged by activation of specific projection areas. The final goal is to use immediate-early genes and viral tracing of VMH projections to target the neurons involved in aggression, and investigate dendritic information processing in this specific cell population.
Where is this data from?
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Grant Details
Amount Awarded | 982482 |
Applicant Surname | Branco |
Approval Committee | Sir Henry Dale Fellowship Interview Committee |
Award Date | 2012-06-11T00:00:00+00:00 |
Financial Year | 2011/12 |
Grant Programme: Title | Sir Henry Dale Fellowship |
Internal ID | 098400/Z/12/Z |
Lead Applicant | Prof Tiago Branco |
Partnership Name | Royal Society/Wellcome Trust Sir Henry Dale Fellowship |
Partnership Value | 982482 |
Planned Dates: End Date | 2016-06-30T00:00:00+00:00 |
Planned Dates: Start Date | 2012-11-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South West |
Sponsor(s) | Dr Michel Goedert |