Whole-heart phosphorus spectroscopy at 7 tesla enabled by a whole-body transmit coil (360G-Wellcome-098436_Z_12_A)

£200,000

31P magnetic resonance spectroscopy (31P-MRS) has already contributed significantly to our understanding of cardiac metabolism. However, its great promise has so far gone largely untapped because technical limitations require comparatively long acquisitions which have relatively low spatial resolution. The ability to quantify metabolites in each of the 17 cardia segments in under 20 minutes, ideally from a single subject, would represent a step change in the clinical potential of 31P-MRS. To accomplish this, every stage in the protocol for 31P-MRS must be optimised because improvements at each stage are cumulative. Therefore, I propose to address the hardware used for cardiac 31P-MRS, the acquisition pulse sequence, the reconstruction of the acquired data and the post-processing of spectra to estimate metabolite concentrations. The most significant gains are likely to arise by increasing the magnetic field strength from 3T to 7T by employing the UK's first cardiac-capable 7T MRI sc anner, which has just been installed in Oxford, to collect the first cardiac 7T 31P spectra. My proposed visits to leading experts in the USA will build on my existing expertise in 31P-MRS and cardiac 7T magnetic resonance, positioning me well to be at the forefront of future developments in this field.

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Grant Details

Amount Awarded 200000
Applicant Surname Rodgers
Approval Committee Science Enhancement Committee
Award Date 2016-04-08T00:00:00+00:00
Financial Year 2015/16
Grant Programme: Title Enhancement
Internal ID 098436/Z/12/A
Lead Applicant Prof Christopher Rodgers
Partnership Value 200000
Planned Dates: End Date 2017-10-25T00:00:00+00:00
Planned Dates: Start Date 2016-04-25T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East