Whole-heart phosphorus spectroscopy at 7 tesla enabled by a whole-body transmit coil (360G-Wellcome-098436_Z_12_A)
31P magnetic resonance spectroscopy (31P-MRS) has already contributed significantly to our understanding of cardiac metabolism. However, its great promise has so far gone largely untapped because technical limitations require comparatively long acquisitions which have relatively low spatial resolution. The ability to quantify metabolites in each of the 17 cardia segments in under 20 minutes, ideally from a single subject, would represent a step change in the clinical potential of 31P-MRS. To accomplish this, every stage in the protocol for 31P-MRS must be optimised because improvements at each stage are cumulative. Therefore, I propose to address the hardware used for cardiac 31P-MRS, the acquisition pulse sequence, the reconstruction of the acquired data and the post-processing of spectra to estimate metabolite concentrations. The most significant gains are likely to arise by increasing the magnetic field strength from 3T to 7T by employing the UK's first cardiac-capable 7T MRI sc anner, which has just been installed in Oxford, to collect the first cardiac 7T 31P spectra. My proposed visits to leading experts in the USA will build on my existing expertise in 31P-MRS and cardiac 7T magnetic resonance, positioning me well to be at the forefront of future developments in this field.
Where is this data from?
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Grant Details
Amount Awarded | 200000 |
Applicant Surname | Rodgers |
Approval Committee | Science Enhancement Committee |
Award Date | 2016-04-08T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Enhancement |
Internal ID | 098436/Z/12/A |
Lead Applicant | Prof Christopher Rodgers |
Partnership Value | 200000 |
Planned Dates: End Date | 2017-10-25T00:00:00+00:00 |
Planned Dates: Start Date | 2016-04-25T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |