Human to mosquito transmission of dengue virsues and Wolbachia-mediated interference of vector competence (360G-Wellcome-098541_Z_12_Z)
This research training fellowship will identify immunological and virological correlates of human-tomosquito dengue virus transmission. I will do this using a combination of clinical studies (direct exposure of mosquitoes to viremic humans), immunological measurements of the antibody response and virological assessments of the viral load in the patients blood and also in the mosquito. This fellowship will also measure the ability of different strains of Wolbachia, a common intracellular bacterial symbiont of insects, to block dengue virus infection in Vietnamese Aedes aegypti mosquitoes. These investigations will be performed with clinical material (blood from dengue patients) and provide a robust assessment of the potential for Wolbachia as a means of controlling dengue transmission.
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Grant Details
| Amount Awarded | 204593 |
| Applicant Surname | Tran Nguyen |
| Approval Committee | International Interview Committee |
| Award Date | 2012-12-06T00:00:00+00:00 |
| Financial Year | 2012/13 |
| Grant Programme: Title | International Training Fellowship |
| Internal ID | 098541/Z/12/Z |
| Lead Applicant | Dr Chau Tran Nguyen |
| Partnership Value | 204593 |
| Planned Dates: End Date | 2016-07-31T00:00:00+00:00 |
| Planned Dates: Start Date | 2013-02-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |
| Sponsor(s) | Prof Guy Thwaites |