Biological determinants of ageing and late life health, and their pharmacological manipulation. (360G-Wellcome-098565_Z_12_Z)

£4,847,435

Age is the main risk factor for common, debilitating conditions including cancer, cardiovascular disease and neurodegeneration. Single gene mutations can extend healthy lifespan in laboratory animals. The mechanisms involved are evolutionarily conserved, with genetic and pharmacological inhibition of the nutrient-sensing insulin/insulin-like growth factor/TOR (IIT) signalling network extending healthy lifespan in yeast, nematode worms, fruit flies and mammals. Dietary restriction (DR) also exten ds healthy lifespan in these organisms, at least in part through altered IIT activity. Both reduced IIT activity and DR induce a broad-spectrum improvement in health and protection against pathology during ageing. Thus, amelioration of the ageing process can protect against diseases of ageing. This programme will have three key goals: 1. To discover how reduced activity IIT activity improves health during ageing, through experimental analysis of signalling and effector mechanisms in model orga nisms; 2 To recapitulate and extend improved health during ageing by pharmacological manipulation of key target molecules, both with existing drugs and new probe molecules; 3. To use results generated in 1 and 2, together with population genetic and drug response information from humans, to translate the discoveries into improvement in health of older people.

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Grant Details

Amount Awarded 4847435
Applicant Surname Partridge
Approval Committee Strategic Awards Committee
Award Date 2012-04-17T00:00:00+00:00
Financial Year 2011/12
Grant Programme: Title Strategic Award - Science
Internal ID 098565/Z/12/Z
Lead Applicant Prof Linda Partridge
Other Applicant(s) Prof David Gems, Prof Dominic Withers, Prof Janet Thornton
Partnership Value 4847435
Planned Dates: End Date 2021-12-30T00:00:00+00:00
Planned Dates: Start Date 2013-04-03T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London