Translating whole genome sequence technology into diagnostic and public health microbiology (360G-Wellcome-098600_Z_12_Z)

£2,510,121

Effective mechanisms of surveillance are required to track disease trends, identify new infectious disease threats, detect serious outbreaks, monitor control measures, design effective vaccines and monitor for vaccine escape. The present public health system falls short of what is required because of a technology gap whereby it is not possible to make rapid or in some cases accurate inferences regarding pathogen outbreaks and transmission events using the currently available microbial genotyping methodology.Through this award to Cambridge University, Professor Sharon Peacock will seek a solution to this need through the development of a world-class system of active surveillance based on microbial whole genome sequencing (WGS), in collaboration with the Cambridge University Hospitals NHS Trust, the Health Protection Agency and the Wellcome Trust Sanger Institute. The aim is to embed a genome sequence-driven microbiology initiative within a clinical campus, working alongside a hospital diagnostic and public health laboratory. Key objectives are to understand how to apply genomics to address the problems of infectious disease control scaled to local, regional or national levels, and how to integrate this technology into on-going practice so as to expand and enhance the current system of infectious diseases surveillance conducted.

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Grant Details

Amount Awarded 2510121
Applicant Surname Peacock
Approval Committee Health Innovation Challenge Fund
Award Date 2012-04-27T00:00:00+00:00
Financial Year 2011/12
Grant Programme: Title Health Innovation Challenge Fund Award
Internal ID 098600/Z/12/Z
Lead Applicant Prof Sharon Peacock
Other Applicant(s) Dr Christine McCartney, Prof Gordon Dougan, Prof Julian Parkhill, Prof Stephen Bentley
Partnership Name Health Innovation Challenge Fund
Partnership Value 4461950
Planned Dates: End Date 2021-06-30T00:00:00+00:00
Planned Dates: Start Date 2013-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England