InterMine and humanMine - enhancing the biomedical relevance of model organisms and enabling other data mining projects. (360G-Wellcome-099133_Z_12_Z)

Five of the major Model Organism Databases (MODs) have adopted the InterMine data integration platform to provide flexible searching and data mining interfaces to their user communities, the first time these widely used resources have converged on a common software platform. Furthermore InterMine is becoming established as a major platform for data integration by other projects. A challenge for modern biology and a key aim of the MODs in using InterMine, is to promote interoperability and cro ss organism integrative analysis. A unique opportunity exists to create a human InterMine resource that, via the same mechanism of inter-operation, will provide uniform medically relevant human data to model organism research communities. Simultaneously the biomedical research community will gain simple access to the wealth of model organism research. We request 5-year support (1) to maintain and develop the core InterMine infrastructure on which the above projects depend, including devel oping MOD/human integrative analysis tools; (2) to build and maintain an integrated human InterMine database with which the MODs and other users can interoperate. These developments will have an impact by facilitating the research carried out by the thousands of MOD users worldwide and also users of other InterMine-based databases.