Next Generation Approaches to characterise Adaptive Stress Surveillance by Gamma Delta T cells (360G-Wellcome-099266_Z_12_A)

£157,480

This application builds on Prof Willcox’ recent research that re-evaluates how human gammadelta T-cells function. Previously gammadelta T-cells were thought to be "innate-like" T-cells, providing rapid surveillance to cellular stress without the need for clonal expansion and differentiation. Our study (Davey et al, submitted to Science Immunology) indicates that although Vgamma9Vdelta2 T-cells apparently fit this paradigm, Vdelta1 T-cells, present in blood and predominant in tissues, have a radically different adaptive biology, involving pronounced clonal expansion, and differentiation from naïve to effector phenotype. We have termed this biology ‘ADaptive Stress Surveillance’ (ADSS) (Figure 1). These recent findings, combined with our strategic combination of aligned ‘next generation’ techniques (TCR repertoire analysis, single cell PCR, single cell transcriptomics/TCR assignment; in situ gammadelta Tcell imaging) place us in a unique position and timepoint to further investigate ADSS via this award.

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Grant Details

Amount Awarded 157480
Applicant Surname Willcox
Approval Committee Science Enhancement Committee
Award Date 2016-12-05T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Enhancement
Internal ID 099266/Z/12/A
Lead Applicant Prof Benjamin Willcox
Partnership Value 157480
Planned Dates: End Date 2020-05-31T00:00:00+00:00
Planned Dates: Start Date 2017-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region West Midlands