Next Generation Approaches to characterise Adaptive Stress Surveillance by Gamma Delta T cells (360G-Wellcome-099266_Z_12_A)
This application builds on Prof Willcox’ recent research that re-evaluates how human gammadelta T-cells function. Previously gammadelta T-cells were thought to be "innate-like" T-cells, providing rapid surveillance to cellular stress without the need for clonal expansion and differentiation. Our study (Davey et al, submitted to Science Immunology) indicates that although Vgamma9Vdelta2 T-cells apparently fit this paradigm, Vdelta1 T-cells, present in blood and predominant in tissues, have a radically different adaptive biology, involving pronounced clonal expansion, and differentiation from naïve to effector phenotype. We have termed this biology ‘ADaptive Stress Surveillance’ (ADSS) (Figure 1). These recent findings, combined with our strategic combination of aligned ‘next generation’ techniques (TCR repertoire analysis, single cell PCR, single cell transcriptomics/TCR assignment; in situ gammadelta Tcell imaging) place us in a unique position and timepoint to further investigate ADSS via this award.
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Grant Details
Amount Awarded | 157480 |
Applicant Surname | Willcox |
Approval Committee | Science Enhancement Committee |
Award Date | 2016-12-05T00:00:00+00:00 |
Financial Year | 2016/17 |
Grant Programme: Title | Enhancement |
Internal ID | 099266/Z/12/A |
Lead Applicant | Prof Benjamin Willcox |
Partnership Value | 157480 |
Planned Dates: End Date | 2020-05-31T00:00:00+00:00 |
Planned Dates: Start Date | 2017-01-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | West Midlands |