PDGF as a cell autonomous regulator of Epithelial-to-Mesenchymal-Transition (EMT) in neural crest cells. (360G-Wellcome-099746_Z_12_A)
A defining characteristic of neural crest (NC) cells is the epithelial-to?mesenchymal transition (EMT) they undergo to segregate from the neural tube to start migration. EMT is a cellular process converting non-motile epithelial cells to motile mesenchymal cells, showing strikingly common characteristics in metastatic cancer cells and NC cells. Preliminary data suggests that PDGF signalling is required cell-autonomously for NC cell migration in Xenopus laevis embryos whereas PDGF loss-of-function is sufficient to inhibit EMT in in vitro cultures. The proposed project aims to investigate cellular and Molecular mechanisms governed by PDGF during EMT of NC and to extrapolate the gained knowledge onto cancer cell metastasis. We will perform high-resolution time-lapse video analysis of NC EMT comparing gain-of-function and loss-of-function of PDGF in vivo and in vitro. Further study will aim to identify the pathways and downstream targets triggered by PDGF signalling. Finally the gained knowledge will be used to study EMT in cancer cell lines and a transparent zebrafish model allowing the live-imaging
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Grant Details
| Amount Awarded | 41973 |
| Applicant Surname | Bahm |
| Approval Committee | PhD Studentships |
| Award Date | 2014-01-17T00:00:00+00:00 |
| Financial Year | 2013/14 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 099746/Z/12/A |
| Lead Applicant | Ms Isabel Bahm |
| Partnership Value | 41973 |
| Planned Dates: End Date | 2016-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2013-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Greater London |
| Sponsor(s) | Prof Claudio Stern |