Role of interleukin 33 in intestinal homeostasis (360G-Wellcome-099814_Z_12_A)
This research project will focus on the identification of the role of interleukin 33 (IL-33) in intestinal homeostasis. IL-33 belongs to the IL-1 family and has been shown to mediate both pro-inflammatory and anti-inflammatory processes depending on the disease context. Although IL-33 is produced in high amounts in the intestine little is known about its role ininflammatory bowel disease (IBD) development and progression. In this project I will use in vitro and in vivo systems, including knock-out and reporter mouse strains, in order to describe IL-33 signalling in the gut. Recent studies suggest that intestinal regulatory T cells (Tregs) express high levelsof IL-33R and that this pathway contributes to their function. I will build onthese studies to identify key downstream pathways activated by IL-33 in Treg cells that promote their function and how these are regulated by pro-inflamamtory mediators. Altogether the results of this study may lead to identification of potential novel therapeutic targets in IBD.
Where is this data from?
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Grant Details
Amount Awarded | 61536 |
Applicant Surname | Chomka |
Approval Committee | PhD Studentships |
Award Date | 2014-01-17T00:00:00+00:00 |
Financial Year | 2013/14 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 099814/Z/12/A |
Lead Applicant | Ms Agnieszka Chomka |
Partnership Value | 61536 |
Planned Dates: End Date | 2016-12-31T00:00:00+00:00 |
Planned Dates: Start Date | 2013-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | South East |
Sponsor(s) | Prof Keith Gull |