The role of MlR137 and its targets in associative learning. (360G-Wellcome-099821_Z_12_Z)
We aim to determine the role of miR-137 and its targets in associative learning by investigating gene expression during contextual fear conditioning, a rodent model of hippocampal associative plasticity. Allelic variation in MIR137 and a sub-set of its confirmed targets has been associatedwith increased risk of schizophrenia in the latest GWAS. The aim is to focus on the regulation of calcium channel genes by miR-137, including the confirmedtarget CACNA1C, as well as other putative targets found to be associated withschizophrenia. Research would progress to explore the effects of local inhibition of calcium channels in the hippocampus as well as characterisation of a transgenic CACNA1C knock-out model. We further aim to confirm or refute predicted targets of miR-137 that may advance our understanding of this potential pathological pathway contributing to the etiology of schizophrenia.
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Grant Details
| Amount Awarded | 150112 |
| Applicant Surname | Sykes |
| Approval Committee | PhD Studentships |
| Award Date | 2012-06-25T00:00:00+00:00 |
| Financial Year | 2011/12 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 099821/Z/12/Z |
| Lead Applicant | Ms Lucy Sykes |
| Partnership Value | 150112 |
| Planned Dates: End Date | 2016-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2012-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Wales |
| Sponsor(s) | Prof Vincenzo Crunelli |