How does memory inflation occur? Analysis using novel adenovirus constructs (360G-Wellcome-099897_Z_12_A)
The research is aimed at a basic immunologic question highlighted through murine cytomegalovirus (MCMV) infection, which is how does memory "inflation" occur? In other words, what are the basic molecular and cellular components that are required in order to generate sustained high frequency effector memory responses? In particular, I am going to use a novel, simplified system developed in the lab to probe the impact of the viral promotor, cellular processing and innate signalling. There are two principal aims: 1. To test the hypothesis that the viral promotor dictates memory inflation. Using the model adenoviral system I will assess the impact of modifying the viral promotor on memory inflation. 2. To test the hypothesis that cellular antigen processing dictates memory inflation. Using the model adenovirus system I will assess the impact modifying the antigenic context of the peptide epitope on memory inflation. epitope on memory inflation.
Where is this data from?
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Grant Details
| Amount Awarded | 29530 |
| Applicant Surname | Colston |
| Approval Committee | PhD Studentships |
| Award Date | 2012-09-17T00:00:00+00:00 |
| Financial Year | 2011/12 |
| Grant Programme: Title | PhD Training Fellowship for Clinicians |
| Internal ID | 099897/Z/12/A |
| Lead Applicant | Dr Julia Colston |
| Partnership Value | 29530 |
| Planned Dates: End Date | 2015-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2012-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | South East |
| Sponsor(s) | Prof Rajesh Thakker |