Deciphering the Mechanisms of Developmental Disorders (DMDD). (360G-Wellcome-100160_B_12_Z)

£2,683,074

The proposal aims to capitalize on the unique resource of knockout mouse strains being generated by the Sanger Institute Mouse Genetics Project pipeline. Over the next 5 years the MGP primary screen will identify in excess of 250 genes essential for normal development. The DMDD project will employ high throughput imaging ( CT and HREM) of mutant embryos to identify and catalog structural developmental defects. Possible contributions resulting from disturbed placental development will be assess ed. Phenotypic characterization in conjunction with high-throughput transcriptomic analysis at defined developmental stages will provide new information about gene regulatory networks underpinning normal development. The efforts of the DMDD project will be guided by interactions with Deciphering Developmental Disorders and the MRC Developmental Anomalies Consortia, to prioritize generation and analysis of mutants in mouse genes orthologous to disease alleles identified by human genetic studies. The major output of DMDD will be a single, publicly-available database, fully linked into the International Mouse Phenotyping Consortium and designed to facilitate access by the clinical and developmental biology community. Our goals are dissemination of primary phenotyping information, encouraging maximal uptake of mutant strains by laboratories for future in-depth analysis and advancing identification of developmental disease alleles.

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Grant Details

Amount Awarded 2683074
Applicant Surname Stratton
Approval Committee Strategic Awards Committee
Award Date 2012-10-12T00:00:00+00:00
Financial Year 2012/13
Grant Programme: Title Sanger Resource Collaboration
Internal ID 100160/B/12/Z
Lead Applicant Prof Sir Michael Stratton
Partnership Value 2683074
Planned Dates: End Date 2018-07-31T00:00:00+00:00
Planned Dates: Start Date 2013-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England