1 year extension application (360G-Wellcome-100171_Z_12_B)
This fellowship investigates the incompletely understood processes underlying worsened acute kidney injury (AKI) and impaired renal regeneration in the elderly. My collaborators have recently demonstrated that young recruited monocytes can restore successful repair in other aging organ systems. I hypothesise that altered monocyte/macrophage behaviour impairs regeneration after renal injury in the elderly I will: 1) Dissect the contibution of the aging immune system, the renal parenchyma, or the interplay of both in determining the regenerative potential of the aged injured kidney. 2) Define how these responses can be manipulated to enhance renal repair after injury. To address these issues, with my collaborators at Harvard University I will establish a model of AKI in parabiotic mouse pairings. This will permit incisive experiments examining the impact of old + young circulating cells recruiting to the same injured kidney, and the cross-talk between these cells and the old or young parenchyma. Goals: 1. Characterise the effects of aging macrophage phenotype on maximal severity of AKI 2. Investigate reparative macrophage phenotypes and parenchymal responses in the aged regenerating kidney 3: Dissect interactions of aged macrophages and apoptotic and viable parenchymal cells in vitro
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
| Amount Awarded | 264314 |
| Applicant Surname | Ferenbach |
| Approval Committee | Internal Decision Panel |
| Award Date | 2018-09-30T00:00:00+00:00 |
| Financial Year | 2017/18 |
| Grant Programme: Title | Intermediate Clinical Fellowship |
| Internal ID | 100171/Z/12/B |
| Lead Applicant | Dr David Ferenbach |
| Partnership Value | 264314 |
| Planned Dates: End Date | 2019-08-01T00:00:00+00:00 |
| Planned Dates: Start Date | 2018-02-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Scotland |