'Centre for Health service and Academic Partnership in Translational eHealth Research (CHAPTER)' (360G-Wellcome-100663_Z_12_Z)

UCL Partners is the largest AHSC in terms of population served (5m, ethnically diverse), and concentration of BRCs (n=5, £165m) and is the only AHSC with a system wide partnership model (n=14 NHS Trusts). Bringing together three of UCLP's academic partners UCL, LSHTM and QMUL, and the HPA, CHAPTER will integrate for the first time multiple areas of critical mass ( > 60 data sources and > 30 cross Faculty research groups with informatics expertise) in order to deliver our vision of driving the next generation of population wide translational research. With UCL as host institution committing £4m to CHAPTER, and NHS partners investing significantly in new integration systems (across primary and secondary care), we will deliver impact across the whole translational cycle from biological discovery including omics and digital phenotyping with imaging through innovative trials to improving clinical practice, service delivery, patient outcomes and public health. Specifically CHAPTER will: A answer important research questions, aligned with our BRCs: initially in cardiovascular medicine, maternal and child health, and infection. These will link and exploit both UCLP primary and secondary care datasets and our national collections with > 1m patients in cardiovascular (UCL, NICOR), mother and child and infection (HPA, LabBase). B establish a new integrated informatics and biostatistics platform to underpin translational research. C establish an Academy of Translational eHealth for inter-disciplinary training of clinicians, academics and those in enabling roles. D implement consent as part of care across UCL Partner organisations and develop innovative public engagement programmes. These four areas of work will provide launch pads for programme grant applications for further research for patient benefit as well as laying the foundation for extending CHAPTER research into neurodegeneration and other areas of BRC funding.