Protecting organ function in severe trauma/haemorrhage using the anti-malarial drug artesunate (360G-Wellcome-101012_Z_13_Z)
Trauma is the most frequent cause of death in people under the age of 40. Despite resuscitation in the emergency room, severe blood loss can lead to the dysfunction of vital organs (kidney, lung, heart, liver, brain), which ultimately may cause the death of a trauma patient. At present there are no specific treatments for organ failure in routine clinical use, and management is only supportive.A research group headed by Professor Christoph Thiemermann at Queen Mary University of London, has discovered that small doses of a commonly used and safe anti-malarial drug (artesunate), reduces multiple organ failure after trauma-haemorrhage in a rat model. The team at Queen Mary's plan to conduct a trial with artesunate in patients with trauma and severe haemorrhage. The team hopes to demonstrate that this therapeutic agent is safe and also effective at reducing the incidence and severity of multiple organ failure. This early treatment of trauma patients against organ failure could have a major positive global impact on patient outcomes and resource utilisation.
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Grant Details
Amount Awarded | 325444 |
Applicant Surname | Thiemermann |
Approval Committee | Health Innovation Challenge Fund |
Award Date | 2013-04-25T00:00:00+00:00 |
Financial Year | 2012/13 |
Grant Programme: Title | Health Innovation Challenge Fund Award |
Internal ID | 101012/Z/13/Z |
Lead Applicant | Prof Christoph Thiemermann |
Other Applicant(s) | Prof Karim Brohi |
Partnership Name | Health Innovation Challenge Fund |
Partnership Value | 758403 |
Planned Dates: End Date | 2020-12-31T00:00:00+00:00 |
Planned Dates: Start Date | 2015-04-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |