Protecting organ function in severe trauma/haemorrhage using the anti-malarial drug artesunate (360G-Wellcome-101012_Z_13_Z)

£325,444

Trauma is the most frequent cause of death in people under the age of 40. Despite resuscitation in the emergency room, severe blood loss can lead to the dysfunction of vital organs (kidney, lung, heart, liver, brain), which ultimately may cause the death of a trauma patient. At present there are no specific treatments for organ failure in routine clinical use, and management is only supportive.A research group headed by Professor Christoph Thiemermann at Queen Mary University of London, has discovered that small doses of a commonly used and safe anti-malarial drug (artesunate), reduces multiple organ failure after trauma-haemorrhage in a rat model. The team at Queen Mary's plan to conduct a trial with artesunate in patients with trauma and severe haemorrhage. The team hopes to demonstrate that this therapeutic agent is safe and also effective at reducing the incidence and severity of multiple organ failure. This early treatment of trauma patients against organ failure could have a major positive global impact on patient outcomes and resource utilisation.

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Grant Details

Amount Awarded 325444
Applicant Surname Thiemermann
Approval Committee Health Innovation Challenge Fund
Award Date 2013-04-25T00:00:00+00:00
Financial Year 2012/13
Grant Programme: Title Health Innovation Challenge Fund Award
Internal ID 101012/Z/13/Z
Lead Applicant Prof Christoph Thiemermann
Other Applicant(s) Prof Karim Brohi
Partnership Name Health Innovation Challenge Fund
Partnership Value 758403
Planned Dates: End Date 2020-12-31T00:00:00+00:00
Planned Dates: Start Date 2015-04-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London