Mutant p53 enhances receptor recycling to enhance invasion and chemo-resistance. (360G-Wellcome-101242_Z_13_Z)
The majority of the malignant tumours contain mutations in p53 resulting in the expression of a mutant p53 protein. This protein has not only lost its transcriptional tumour suppressive functions, but has also gained novel functions in driving metastasis and developing resistance to chemotherapy. To a certain extent these novel functions comprise mutant p53s ability to inhibit other transcription factors, including p63. The overall aim of my research program is to better understand the processes underlying mutant p53 gain-of-function in invasion and chemo-resistance. The key goals of my proposed research are: (1) To further characterise the inhibitory role of mutant p53 on p63. (2) To explore the role of mutant p53 in the regulation of Dicer (a target gene of p63) and microRNA biosynthesis. (3) To characterise the role of mutant p53 (and loss of p63) in chemo-resistance and to demonstrate a role for multidrug receptor recycling in chemo-resistance. (4) To assess the role of the mic roenvironment in the behaviour of mutant p53 cells to chemo-therapy.
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Grant Details
Amount Awarded | 831980 |
Applicant Surname | Muller |
Approval Committee | Sir Henry Dale Fellowship Interview Committee |
Award Date | 2013-05-29T00:00:00+00:00 |
Financial Year | 2012/13 |
Grant Programme: Title | Sir Henry Dale Fellowship |
Internal ID | 101242/Z/13/Z |
Lead Applicant | Dr Patricia Muller |
Partnership Name | Royal Society/Wellcome Trust Sir Henry Dale Fellowship |
Partnership Value | 831980 |
Planned Dates: End Date | 2017-10-23T00:00:00+00:00 |
Planned Dates: Start Date | 2014-01-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East Midlands |
Sponsor(s) | Prof Anne Willis |