Mutant p53 enhances receptor recycling to enhance invasion and chemo-resistance. (360G-Wellcome-101242_Z_13_Z)

£831,980

The majority of the malignant tumours contain mutations in p53 resulting in the expression of a mutant p53 protein. This protein has not only lost its transcriptional tumour suppressive functions, but has also gained novel functions in driving metastasis and developing resistance to chemotherapy. To a certain extent these novel functions comprise mutant p53s ability to inhibit other transcription factors, including p63. The overall aim of my research program is to better understand the processes underlying mutant p53 gain-of-function in invasion and chemo-resistance. The key goals of my proposed research are: (1) To further characterise the inhibitory role of mutant p53 on p63. (2) To explore the role of mutant p53 in the regulation of Dicer (a target gene of p63) and microRNA biosynthesis. (3) To characterise the role of mutant p53 (and loss of p63) in chemo-resistance and to demonstrate a role for multidrug receptor recycling in chemo-resistance. (4) To assess the role of the mic roenvironment in the behaviour of mutant p53 cells to chemo-therapy.

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Grant Details

Amount Awarded 831980
Applicant Surname Muller
Approval Committee Sir Henry Dale Fellowship Interview Committee
Award Date 2013-05-29T00:00:00+00:00
Financial Year 2012/13
Grant Programme: Title Sir Henry Dale Fellowship
Internal ID 101242/Z/13/Z
Lead Applicant Dr Patricia Muller
Partnership Name Royal Society/Wellcome Trust Sir Henry Dale Fellowship
Partnership Value 831980
Planned Dates: End Date 2017-10-23T00:00:00+00:00
Planned Dates: Start Date 2014-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East Midlands
Sponsor(s) Prof Anne Willis