Psychosis risk over the life course: A multilevel, longitudinal investigation of social, economic and physical environmental risk factors at different stages in life. (360G-Wellcome-101272_Z_13_Z)

£700,322

I propose four multilevel, spatial and longitudinal epidemiological studies to answer my research question. Study 1 will examine the spatial distribution of non-affective and affective psychotic disorders and symptoms over the life-course (i.e. birth, 5 years, 15 years, onset) to determine whether, and if so when, these outcomes show different socio-spatial patterning. I will apply Bayesian spatial latent structure models to two datasets (ALSPAC birth cohort, Swedish Register data) in order to t est this question. Study 2 will investigate the relative roles of social, economic and physical environmental factors on psychosis risk over the life course. I will investigate different theoretical models by applying survival-based spatial SEM to Swedish longitudinal data to investigate the direct and mediating pathways through which social and physical environment factors influence psychosis risk over the life course. Study 3 will investigate whether moving between neighbourhoods in childhood is associated with psychiatric symptomatology in adolescence, using latent class analysis to model neighbourhood trajectories in relation to psychiatric symptoms in two cohorts (ALSPAC; National Longitudinal Survey of Children and Youth, Canada). Study 4 will use Swedish data to investigate whether timing of maternal immigration is related to offspring psychosis risk, as reported for autism spectrum disorders.

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Grant Details

Amount Awarded 700322
Applicant Surname Kirkbride
Approval Committee Sir Henry Dale Fellowship Interview Committee
Award Date 2013-05-29T00:00:00+00:00
Financial Year 2012/13
Grant Programme: Title Sir Henry Dale Fellowship
Internal ID 101272/Z/13/Z
Lead Applicant Prof James Kirkbride
Partnership Name Royal Society/Wellcome Trust Sir Henry Dale Fellowship
Partnership Value 700322
Planned Dates: End Date 2019-12-31T00:00:00+00:00
Planned Dates: Start Date 2014-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Michael King