Psychosis risk over the life course: A multilevel, longitudinal investigation of social, economic and physical environmental risk factors at different stages in life. (360G-Wellcome-101272_Z_13_Z)
I propose four multilevel, spatial and longitudinal epidemiological studies to answer my research question. Study 1 will examine the spatial distribution of non-affective and affective psychotic disorders and symptoms over the life-course (i.e. birth, 5 years, 15 years, onset) to determine whether, and if so when, these outcomes show different socio-spatial patterning. I will apply Bayesian spatial latent structure models to two datasets (ALSPAC birth cohort, Swedish Register data) in order to t est this question. Study 2 will investigate the relative roles of social, economic and physical environmental factors on psychosis risk over the life course. I will investigate different theoretical models by applying survival-based spatial SEM to Swedish longitudinal data to investigate the direct and mediating pathways through which social and physical environment factors influence psychosis risk over the life course. Study 3 will investigate whether moving between neighbourhoods in childhood is associated with psychiatric symptomatology in adolescence, using latent class analysis to model neighbourhood trajectories in relation to psychiatric symptoms in two cohorts (ALSPAC; National Longitudinal Survey of Children and Youth, Canada). Study 4 will use Swedish data to investigate whether timing of maternal immigration is related to offspring psychosis risk, as reported for autism spectrum disorders.
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Grant Details
Amount Awarded | 700322 |
Applicant Surname | Kirkbride |
Approval Committee | Sir Henry Dale Fellowship Interview Committee |
Award Date | 2013-05-29T00:00:00+00:00 |
Financial Year | 2012/13 |
Grant Programme: Title | Sir Henry Dale Fellowship |
Internal ID | 101272/Z/13/Z |
Lead Applicant | Prof James Kirkbride |
Partnership Name | Royal Society/Wellcome Trust Sir Henry Dale Fellowship |
Partnership Value | 700322 |
Planned Dates: End Date | 2019-12-31T00:00:00+00:00 |
Planned Dates: Start Date | 2014-01-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |
Sponsor(s) | Prof Michael King |