The hippocampus, sleep and memory consolidation (360G-Wellcome-101759_Z_13_A)
My first goal is to provide a unified and mechanistic account of how the hippocampus supports episodic memory, imagining the future and spatial navigation. I will leverage this long-standing question by eschewing traditional notions regarding the architecture of memory and instead invoke the idea that scenes are central to hippocampal information-processing. This new direction is motivated by my recent discovery that the hippocampus is constantly constructing scenes; automatically anticipating and synthesising representations of the world beyond the immediate sensorium. I will characterise the precise relationship between scenes and hippocampal function, and then establish whether an inability to construct scenes explains impairments in memory, imagination and navigation arising from hippocampal pathology. Capitalising on newly-developed fMRI methods, I recently identified neural signatures of specific recent and remote episodic memories. My second goal is to exploit this new l ine of investigation to determine the exact timescale of hippocampal involvement in episodic memory, a key issue which currently lacks consensus. My third goal is to definitively establish what aspects of hippocampal processing are distinct from neighbouring brain areas, specifically the parahippocampal and retrosplenial cortices. Informed by my recent advances, my strategy abjures the common view that these regions are 'scene-selective' by instead identifying their most basic functions to elucidate their differential contributions to memory. Overall, this new extension of my research could release the hippocampus and related brain regions from currently constrained accounts of their function, with the ambition to provide a theoretically enriched understanding of their fundamental roles and their breakdown in pathology.
Where is this data from?
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Grant Details
Amount Awarded | 155877 |
Applicant Surname | Maguire |
Approval Committee | Science Enhancement Committee |
Award Date | 2015-12-07T00:00:00+00:00 |
Financial Year | 2015/16 |
Grant Programme: Title | Enhancement |
Internal ID | 101759/Z/13/A |
Lead Applicant | Prof Eleanor Maguire |
Partnership Value | 155877 |
Planned Dates: End Date | 2018-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2016-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |