Towards a high definition view of cytoskeleton remodelling by the bacterial pathogen Salmonella. (360G-Wellcome-101828_Z_13_Z)

£1,902,021

What is the detailed biology underlying the intimate interaction of the bacterial pathogen Salmonella with the cytoskeleton of target host cells? In particular, (i) how are the signalling pathways that govern cytoskeletal rearrangements at the host cell membrane controlled by cooperating small GTPases, and (ii) how do secreted virulence effectors of pathogenic Salmonella act specifically and in concert on these signalling networks to effect cell invasion?

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Grant Details

Amount Awarded 1902021
Applicant Surname Koronakis
Approval Committee Science Interview Panel
Award Date 2013-07-10T00:00:00+00:00
Financial Year 2012/13
Grant Programme: Title Investigator Award in Science
Internal ID 101828/Z/13/Z
Lead Applicant Prof Vassilis Koronakis
Partnership Value 1902021
Planned Dates: End Date 2021-12-30T00:00:00+00:00
Planned Dates: Start Date 2014-01-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region East of England