Systems Investigation of Germinal Centre Formation. (360G-Wellcome-102296_Z_13_Z)
Invading pathogens can rapidly infect tissues inducing pathology. The immune system has developed an efficient mechanism for creating large amounts of highly specificantibodies through B lymphocytes undergoing affinity maturation in the germinal centre. The spatial organisation of a germinal center is a key determinant of its efficacy. In order for B cells to achieve high levels of affinity and avidity they must shuttle betweentwo anatomically distinct areas under the influence of specific chemokine gradients. However, the key mechanisms leading to germinal centre formation and chemokine field induction are not well understood. This leads us to ask the following question: Given that germinal centres are heterogeneous structures, how do chemokine mediated signals affect their formation and subsequent spatial organisation; thus determining protective immunity? We propose to combine in silico multi-scale modelling with in vivo experimentation to address our research question and ultimately to gain a novel mechanistic understandingof a complex biological process.
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Grant Details
Amount Awarded | 149673 |
Applicant Surname | Cosgrove |
Approval Committee | PhD Studentships |
Award Date | 2013-06-24T00:00:00+00:00 |
Financial Year | 2012/13 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 102296/Z/13/Z |
Lead Applicant | Mr Jason Cosgrove |
Partnership Value | 149673 |
Planned Dates: End Date | 2017-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2013-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Yorkshire and the Humber |
Sponsor(s) | Prof Deborah Smith |