Systems Investigation of Germinal Centre Formation. (360G-Wellcome-102296_Z_13_Z)

£149,673

Invading pathogens can rapidly infect tissues inducing pathology. The immune system has developed an efficient mechanism for creating large amounts of highly specificantibodies through B lymphocytes undergoing affinity maturation in the germinal centre. The spatial organisation of a germinal center is a key determinant of its efficacy. In order for B cells to achieve high levels of affinity and avidity they must shuttle betweentwo anatomically distinct areas under the influence of specific chemokine gradients. However, the key mechanisms leading to germinal centre formation and chemokine field induction are not well understood. This leads us to ask the following question: Given that germinal centres are heterogeneous structures, how do chemokine mediated signals affect their formation and subsequent spatial organisation; thus determining protective immunity? We propose to combine in silico multi-scale modelling with in vivo experimentation to address our research question and ultimately to gain a novel mechanistic understandingof a complex biological process.

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Grant Details

Amount Awarded 149673
Applicant Surname Cosgrove
Approval Committee PhD Studentships
Award Date 2013-06-24T00:00:00+00:00
Financial Year 2012/13
Grant Programme: Title PhD Studentship (Basic)
Internal ID 102296/Z/13/Z
Lead Applicant Mr Jason Cosgrove
Partnership Value 149673
Planned Dates: End Date 2017-09-30T00:00:00+00:00
Planned Dates: Start Date 2013-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Yorkshire and the Humber
Sponsor(s) Prof Deborah Smith