Understanding the role of mossy cells in the neural dynamics underlying hippocampus-dependent learning and epilepsy. (360G-Wellcome-102376_Z_13_A)

£55,234

The general aim of this project is to define the role of mossy cells in hippocampal circuitry and function. Mossy cells are critical components of hippocampal circuitry required for memory formation and learning. In addition, mossy cell pathological loss is a featureof temporal lobe epilepsy (TLE) rodent models. Previous work has shown that mossy cells are absent in adult mice lacking the transcription factor, Prdm8 and PRDM8 mutations have been implicated in patients with learning disabilities and epilepsy. Initially, in vitro electrophysiology in hippocampal slices will enable physiological analysis to be evaluated, with greater detail considering granule cell activity and morphology. This data will provide the bases for entire hippocampal formation recording in vivo as well as, investigation of seizure activity in the absence of mossy cells. Contextual fear discrimination protocols will be adapted to examine the impact of mossy cell loss on pattern separation. Finally, empirical data will be used to build and elaborate two dentate gyrus (DG) based computational models (Scharfmann and Myers. 2009 and Santhakumar et al., 2005), to understand the effect of mossy cell loss on memory performance and seizure activity in relation to underlying hippocampal neural dynamics.

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Grant Details

Amount Awarded 55234
Applicant Surname Kolaric
Approval Committee PhD Studentships
Award Date 2015-01-30T00:00:00+00:00
Financial Year 2014/15
Grant Programme: Title PhD Studentship (Basic)
Internal ID 102376/Z/13/A
Lead Applicant Ms Katarina Kolaric
Partnership Value 55234
Planned Dates: End Date 2017-09-30T00:00:00+00:00
Planned Dates: Start Date 2014-10-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South West
Sponsor(s) Prof Stafford Lightman