Neuroimaging of functional plasticity in multiple sclerosis. (360G-Wellcome-102403_Z_13_Z)
The aim of this PhD is to determine the disease modifying effect of exercise interventions for Multiple Sclerosis (MS) patients. Aerobic exercise has been shown to slow neurological disease progression and symptom severity in animal models and cross-sectionally in human. Limited intervention data exists and understanding of the relationship between aerobic fitness, MS symptoms and brain structural and functional characteristics is limited. For the main experiment, 30 patients will undergo structural and functional magnetic resonance imaging (MRI) during rest, a CO2 challenge and cognitive tests to assess memory and reaction time. Using MRI techniques we will measure the brain changes following a structured exercise intervention. The key outcome measures will be changes in fitness (VO2 peak), balance, cerebral blood flow (CBF), cerebral blood volume (CBV), grey matter volume (GMV) and white matter microstructural changes assessed using diffusion weighted imaging (DWI). This research add to knowledge of the mechanisms of exercise-related neuroprotection by combining CBF and structuralmeasures before and after an exercise intervention.
Where is this data from?
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Grant Details
| Amount Awarded | 149673 |
| Applicant Surname | Foster |
| Approval Committee | PhD Studentships |
| Award Date | 2013-06-24T00:00:00+00:00 |
| Financial Year | 2012/13 |
| Grant Programme: Title | PhD Studentship (Basic) |
| Internal ID | 102403/Z/13/Z |
| Lead Applicant | Miss Catherine Foster |
| Partnership Value | 149673 |
| Planned Dates: End Date | 2017-09-30T00:00:00+00:00 |
| Planned Dates: Start Date | 2013-10-01T00:00:00+00:00 |
| Recipient Org: Country | United Kingdom |
| Region | Wales |
| Sponsor(s) | Prof Vincenzo Crunelli |