Sulfonium Salts as Precursors for 18F-labelling of Small Molecule PET Tracers. (360G-Wellcome-102407_Z_13_Z)

£163,023

Positron emission tomography (PET) has become an invaluable tool for diagnostic imaging and medical research as it allows quantification of biochemical processes in vivo with unsurpassed sensitivity and specificity. Due to its near ideal physicochemical properties fluorine-18 is the radioisotope of choice for imaging applications with PET, yet the lack of efficient and practical methods for the incorporation of 18F limits the availability of clinically relevant radiotracers. In particular, late stage labelling of compounds bearing functional groups that are prerequisite to biological activity remains challenging. The Arstad group have recently developed a new radiochemical strategy for aromatic labelling of drug-like small molecules based on the unique reactivity of sulfonium salts with fluoride-18. In this project, we aim to investigate the structural requirements for labelling with 18F and to broaden the scope of the existing method by establishing complimentary synthetic routes. To demonstrate clinicalapplicability, the strategy will be used to simplify radiosyntheses of existing radiotracers, to improve the imaging properties of established tracers, and to develop novel diagnostic imaging agents. The work has the potential to open up new prospects for imaging applications with PET. Ultimately, the development of new diagnostic agents can lead to improved human health.

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Grant Details

Amount Awarded 163023
Applicant Surname Cybulska
Approval Committee PhD Studentships
Award Date 2013-06-24T00:00:00+00:00
Financial Year 2012/13
Grant Programme: Title PhD Studentship (Basic)
Internal ID 102407/Z/13/Z
Lead Applicant Miss Klaudia Cybulska
Partnership Value 163023
Planned Dates: End Date 2017-09-23T00:00:00+00:00
Planned Dates: Start Date 2013-09-23T00:00:00+00:00
Recipient Org: Country United Kingdom
Region Greater London
Sponsor(s) Prof Gabriel Waksman