Targeted mRNA Trafficking in Pathfinding Axons of the Developing Visual System. (360G-Wellcome-102457_Z_13_Z)
Building properly wired neural circuits involves guidance of axons towards synaptic targets in the brain. In the growth cone of pathfinding axons, targeted mRNA transport and localised translation is important for autonomously regulating navigational responses tocertain extracellular guidance cues. Still however, axonal mRNA trafficking remains poorly understood. We know very little about which mRNAs are differentially trafficked on guidance cue stimulation or mechanisms underpinning axonal mRNA transport. Using the well-characteriseddeveloping visual system as an experimental platform, this research proposal aims to explore the functional and mechanistic basis of targeted mRNA trafficking during axon guidance. We
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Grant Details
Amount Awarded | 159401 |
Applicant Surname | Turner-Bridger |
Approval Committee | PhD Studentships |
Award Date | 2013-06-24T00:00:00+00:00 |
Financial Year | 2012/13 |
Grant Programme: Title | PhD Studentship (Basic) |
Internal ID | 102457/Z/13/Z |
Lead Applicant | Miss Benita Turner-Bridger |
Partnership Value | 159401 |
Planned Dates: End Date | 2017-09-30T00:00:00+00:00 |
Planned Dates: Start Date | 2013-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | East of England |
Sponsor(s) | Prof Daniel St Johnston |