Effect of exposure to rotavirus vaccine on household rotavirus transmission in a semi-urban Malawian Population. (360G-Wellcome-102466_Z_13_A)

£344,661

Rotavirus is responsible for the deaths of almost 500 000 children under 5 years old annually. Whilst rotavirus vaccination is expected to substantially reduce the burden of severe rotavirus disease worldwide, vaccine efficacy is much lower in resource poor settings. Understanding additional (indirect) benefits of vaccination is therefore extremely important from public health and health economic perspectives. This study will use a prospective cohort design to investigate the impact of rotavirus vaccination of infants on secondary transmission within families in the event of exposure to a symptomatic index rotavirus case. Children with rotavirus gastroenteritis (RVGE) will be recruited and their vaccination status determined. Household contacts of recruited children will be followed up to compare the rotavirus secondary attack rate (SAR) in households exposed to a vaccinated child to SAR in those households unexposed to a vaccinated child. I will i) quantify the difference in SAR for asymptomatic and symptomatic infection in households containing vaccinated versus unvaccinated index children ii) explore the relationship between severity of symptoms in the index child and SAR among household contacts iii) quantify the difference in total household shedding density in households containing vaccinated index children compared to those containing unvaccinated index children using a model of viral shedding derived from intensive sampling in a subset of households.

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Grant Details

Amount Awarded 344661
Applicant Surname Bennett
Approval Committee PhD Studentships
Award Date 2014-08-29T00:00:00+00:00
Financial Year 2013/14
Grant Programme: Title PhD Training Fellowship for Clinicians
Internal ID 102466/Z/13/A
Lead Applicant Dr Aisleen Bennett
Partnership Value 344661
Planned Dates: End Date 2017-08-31T00:00:00+00:00
Planned Dates: Start Date 2014-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region North West
Sponsor(s) Prof David Lalloo, Prof Robert Heyderman