Albumin to prevent infection in Acute-on-Chronic Liver Failure (ATTIRE) (360G-Wellcome-102568_Z_13_Z)
Liver disease is the 5th commonest cause of death in the UK and the only one of the top 10 currently rising. Approximately 110,000 patients with symptoms of advanced cirrhosis, (commonly related to alcohol excess) e.g. jaundice, confusion and bleeding from the stomach, were admitted to UK hospitals in 2011-12. The most common cause of death in these patients is infection. These patients have a weakened immune system making them highly vulnerable to infection and no effective strategy exists to improve this. A research group headed by Dr Alastair O'Brien at University College London discovered that the cause of this vulnerability is an increase in blood levels of a lipid hormone called Prostaglandin E2 (PGE2) which reduces white blood cell function, the cells that fight infection. They have discovered that their immune systems can be boosted for at least 24 hours by infusing albumin into a vein which reduces PGE/s effects. This safe process is currently given when patients need extra fluid e.g. those with kidney damage. They propose this new exciting use for albumin to be given daily to improve cirrhosis patients' immune systems and therefore prevent infection. They hope that this will save lives and reduce health-care costs and propose to investigate this in a large scale clinical trial.
Where is this data from?
This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.
Grant Details
Amount Awarded | 501781 |
Applicant Surname | O'Brien |
Approval Committee | Health Innovation Challenge Fund |
Award Date | 2013-11-28T00:00:00+00:00 |
Financial Year | 2013/14 |
Grant Programme: Title | Health Innovation Challenge Fund Award |
Internal ID | 102568/Z/13/Z |
Lead Applicant | Dr Alastair O'Brien |
Other Applicant(s) | Dr S Ryder, Prof Derek Gilroy, Prof Gianluca Baio, Prof Julia Wendon, Prof Mark Thursz |
Partnership Name | Health Innovation Challenge Fund |
Partnership Value | 1288480 |
Planned Dates: End Date | 2021-03-30T00:00:00+00:00 |
Planned Dates: Start Date | 2014-10-01T00:00:00+00:00 |
Recipient Org: Country | United Kingdom |
Region | Greater London |