Extension of Serial Femtosecond Crystallography (SFX) at the European X-Ray Free Electron Laser (XFEL) (360G-Wellcome-102593_A_13_Z)

£692,010

Third generation synchrotron sources have revolutionised our understanding of the macromolecular machinery of the cell - over 33,000 structures have been elucidated in the last five years, providing atomic detail of macromolecular complexes, membrane proteins and viruses. Fourth generation light sources, such as hard X-ray Free Electron Lasers (XFELs) will allow us to greatly improve one of the bottlenecks of Structural Biology by removing the need for large crystals, which is achieved by outrun ning radiation damage. XFELs also enable sub-picosecond time-resolved analyses and may ultimately provide atomic information for single particles such as viruses and large complexes. The UK is currently not committed to or involved in the construction of a fourth generation light source, including the European XFEL, under construction in Hamburg. This proposal aims to enfranchise the UK structural biology community, amongst the leading in Europe, in this potentially game-changing technology. W e propose to provide training and infrastructure and to directly contribute to the construction and operation of SFX, a user facility for serial femtosecond crystallography at XFEL. An UK Hub at Diamond will allow sample preparation and triage to optimise the use of SFX by UK scientists and maximise the impact of XFEL.

Where is this data from?

This data was originally published by The Wellcome Trust. If you see something about your organisation or the funding it has received on this page that doesn't look right you can submit a grantee amendment request. You can hover over codes from standard codelists to see the user-friendly name provided by 360Giving.

Grant Details

Amount Awarded 692010
Applicant Surname Naismith
Approval Committee Internal Decision Panel
Award Date 2017-09-30T00:00:00+00:00
Financial Year 2016/17
Grant Programme: Title Strategic Award - Science
Internal ID 102593/A/13/Z
Lead Applicant Prof James Naismith
Other Applicant(s) Dr Jan Löwe, Dr Martin Walsh, Prof David Stuart, Prof Henry Chapman
Partnership Value 692010
Planned Dates: End Date 2020-09-30T00:00:00+00:00
Planned Dates: Start Date 2017-09-01T00:00:00+00:00
Recipient Org: Country United Kingdom
Region South East